Evaluación del plan de mantenimiento industrial en el beneficio de café seco ALSACIA (INVERCASA AGROPECUARIA S.A). Matagalpa 2013

El estudio realizado en el beneficio de café seco ALSACIA (INVERCASA AGROPECUARIA S.A), se llevó a cabo con el fin de conocer el plan de mantenimiento empleado por dicha empresa; evaluando así éste para determinar si es el más adecuado para las máquinas involucradas en el proceso de producción. Para ello se utilizó el historial de averías de cada equipo, logrando así conocer la mantenibilidad y fiabilidad, que a su vez nos permitieron definir el grado de disponibilidad de cada máquina. La evaluación realizada nos permitió determinar que la disponibilidad de los equipos no está garantizada en su totalidad, lo que genera paros imprevistos en la línea de producción, incurriendo así en pérdidas para la empresa. Por lo que se pudo definir que el plan de mantenimiento utilizado no es el más adecuado para el proceso de producción ya que a pesar de las actividades preventivas ejecutadas, existen paros, los que resuelven implementando el mantenimiento correctivo inmediato, el que es posible ya que la empresa cuenta con un amplio stock de repuestos. Tomando en cuenta la información procesada del historial de averías de los equipos y la información técnica del dossier para cada una de estas máquinas, se elaboró un plan de mantenimiento preventivo aplicado a las condiciones actuales de trabajo en la empresa. Dicho plan de mantenimiento es el que a través de este estudio proponemos para optimizar el proceso productivo y maximizar las utilidades del beneficio ALSACI

A comparative study of steganography using watermarking and modifications pixels versus least significant bit

This article presents a steganography proposal based on embedding data expressed in base 10 by directly replacing the pixel values from images red, green blue (RGB) with a novel compression technique based on watermarks. The method considers a manipulation of the object to be embedded through a data compression triple process via LZ77 and base 64, watermark from low-quality images, embedded via discrete wavelet transformation-singular value decomposition (DWT-SVD), message embedded by watermark is recovered with data loss calculated, the watermark image and lost data is compressed again using LZ77 and base 64 to generate the final message. The final message is embedded in portable network graphic (PNG) images taken from the Microsoft common objects in context (COCO), ImageNet and uncompressed color image database (UCID) datasets, through a filtering process pixel of the images, where the selected pixels expressed in base 10, and the final message data is embedded by replacing units’ position of each pixel. In experimentation results an average of 40 dB in peak signal noise to ratio (PSNR) and 0.98 in the similarity structural index metric (SSIM) evaluation were obtained, and evasion steganalysis rates of up to 93% for stego-images, the data embedded average is 3.2 bpp

Melhoria da Atenção ao Pré-Natal e Puerpério na Unidade Básica de Saúde Jardim Paraíso, Santana-AP

CABALLERO, Olga Caridad Hector. Melhoria da atenção ao Pré-natal e Puerpério na Unidade Básica de Saúde Jardim Paraíso, Santana-AP. 2015. 109f. Trabalho de Conclusão de Curso (Curso de Especialização em Saúde da Família) - Departamento de Medicina Social, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, 2015. Como indicador extremamente sensível às condições de vida da população, a mortalidade materna reflete, principalmente, a desarticulação, desorganização e baixa qualidade da assistência prestada à saúde da mulher durante o ciclo gravídico-puerperal, sendo que a mortalidade materna e infantil ainda é um problema de saúde pública no Brasil. Por isso o desenvolvimento da atenção ao pré-natal e puerpério na Estratégia de Saúde da Família configura-se como elemento chave no desenvolvimento das ações, através de uma equipe multidisciplinar que atua na promoção de saúde, controle e prevenção de agravos mais frequentes desenvolvidos durante a gravidez e o puerpério. O trabalho apresentado trata de uma intervenção realizada entre os meses de março a junho de 2015, na Unidade Básica de Saúde Jardim Paraíso do município de Santana do estado do Amapá. A mesma está localizada uma área urbana, ocupando desde setembro de 2012 um local emprestado. Antes da intervenção a UBS não contava com registro nem monitoramento dos programas de pré-natal e puerpério. Assim iniciamos o levantamento dos dados mediante o monitoramento constante dos usuários, com o rigoroso preenchimento dos prontuários e planilha de coleta de dados disponibilizados pela especialização. No transcurso da intervenção foi possível cadastrar 100 usuárias gestantes e 23 puérperas, correspondendo respectivamente a 46,7% e 100% de cobertura de pré-natal e puerpério, respectivamente. Durante a intervenção foram indicados a todas as gestantes os exames de laboratório, foram avaliadas as necessidades odontológicas, fez-se a classificação e a estratificação do risco obstétrico. Todas as gestantes tiveram as mamas avaliadas e foi garantido que 100% delas tivessem a prescrição de sulfato ferroso e ácido fólico, obtidos na UBS. Além disso, todas as usuárias cadastradas durante a intervenção receberam ações de promoção em saúde através de orientações sobre alimentação saudável, aleitamento materno, riscos do tabagismo e importância da higiene bucal, cuidados do recém-nascido, aleitamento materno, anticoncepção entre outros temas. É importante destacar que os resultados alcançados só foram possíveis devido à organização que a equipe teve durante o processo, pois pela primeira vez realizou o trabalho como uma verdadeira equipe. Isto pode ser observado na satisfação mostrada pelas gestantes e puérperas, seus familiares e toda comunidade com a intervenção. Conclui-se que o trabalho realizado já foi incorporado à rotina do serviço, melhorando a qualidade na atenção ao pré-natal e puerpério, garantindo uma qualidade de vida saudável para as mães e as crianças. Palavras-chave: Atenção Primária à Saúde; Saúde da família; Saúde da Mulher; Pré-natal; Puerpério; Saúde Bucal

Robotics for facial reconstruction using medical images

The presented study in this paper deals with the development of a cranio-maxillofacial reconstruction system in three dimensions, which will interact with a haptic tool. In turn, a specific robot will be controlled using this tool, which it has installed applications associated with surgery. The proposed system will help physicians gain pre-operative experience, based on reconstructions of three-dimensional images taken from real patients. Good results have been obtained, which validate the proposed system

Immunohistological study of the effect of vascular Endothelial Growth Factor on the angiogenesis of mature root canals in rat molars

Tissue bioengineering has been applied to Endodontics to seek a more biological treatment. The presence of blood vessels is crucial for cell nutrition during tissue formation. Objective: This study analysed the application of vascular endothelial growth factor (VEGF) in the angiogenesis of mature root canals. Material and methods: Upper first molars of twelve 13-week old Wistar male rats were used. The root pulp of the mesiobuccal canal was removed and the root canal instrumented with K-files up to size #25. Periapical bleeding was induced into the root canal by introducing a #15 K-file beyond the apex. The teeth on the right side of the arch were filled up with blood clot (G1), whereas those on the left side were filled up with blood clot plus 50 ng/ml of VEGF (G2). Teeth were sealed with light-curing glass-ionomer cement and the animals were sacrificed after 60 days. The maxilla was dissected and fixed before obtaining serial sections for histological processing with haematoxylin-eosin (HE) and immunohistochemical factor-VIII. Immunohistochemical labelling was evaluated using scores for statistical analysis. Results: Immunohistological analysis demonstrated the presence of angiogenesis in both groups, but with higher angiogenic maturation in G2 during the experimental period (p<0.05). HE staining showed connective tissue with absence of odontoblasts in all specimens. Conclusions: It can be concluded that it is possible to obtain angiogenesis in mature root canals with or without the use of VEGF, although the latter tends to accelerate blood vessel formation

Evaluation of the WaveOne Gold and One Shape New Generation in Reducing Enterococcus faecalis from Root Canal

The aim of this study was to evaluate the WaveOne Gold and One Shape New Generation systems regarding the bacterial removal from root canals infected with Enterococcus faecalis by comparing them to the conventional WaveOne and One Shape systems. Forty-eight distobuccal root canals of maxillary molars sterilized with ethylene oxide were infected with E. faecalis for 21 days, and then root canal initial bacterial sample was collected with paper cones and plated on M-enterococcus agar. The specimens were randomly divided into 4 groups according to the instrumentation: WaveOne Gold, One Shape New Generation, WaveOne and One Shape. After instrumentation, samples were collected with use of scraping and paper cones at immediate and 7 days after instrumentation. The bacterial reduction was calculated and then made intragroup analysis by Friedman test and intergroup analysis by Kruskal-Wallis with Dunn's post-hoc test, all at 5% significance. All techniques significantly reduced the number of bacteria in the root canal (p0.05). Novel single-file systems promote better bacterial removal than the conventional single-file systems

Systematic Procedure to Avoid Unintended Polarity Mismatch in the Cascade Connection of Multiport Devices with Symmetric Feeding Lines

This paper is a postprint of a paper submitted to and accepted for publication in [journal] and is subject to Institution of Engineering and Technology Copyright. The copy of record is available at IET Digital LibraryThe traditional cascading of generalised scattering matrices (GSMs) assumes that the modal sets at the connected ports of a cascaded network are strictly equal. This implies a careful selection of the modal polarities, or the reference systems, of every port. Usually, the connection scheme of every device is known a priori. Then, the individual GSMs are pre-processed, or auxiliary devices, which correct possible modal mismatches at the ports, are included in appropriate positions among the cascade, so that the traditional cascading-by-pairs approach can be directly applied. This scheme clearly complicates the reutilisation of previously calculated GSMs, and mixes the cascading with the solution of the individual building blocks. In this study, a systematic procedure is proposed to define the polarity of the modes at the ports of a device fed with transmission lines or waveguides showing a single or double symmetry. The modified expressions to calculate the scattering parameters of the cascade of two multiport devices, incorporating the regular modal corrections to apply when this criterion is used to define the modal polarity at the ports, is also presented in this study. This strategy is more convenient from the point of view of programming, less error-prone and easier to implement.This work was supported by the Ministry of Science and Innovation, Spanish Government, under Research Projects TEC2013-47037-C05-3-R and TEC2013-47037-C05-1-R.Belenguer Martínez, Á.; Borja, A.; Díaz Caballero, E.; Esteban González, H.; Boria Esbert, VE. (2015). Systematic Procedure to Avoid Unintended Polarity Mismatch in the Cascade Connection of Multiport Devices with Symmetric Feeding Lines. IET Microwaves Antennas and Propagation. 9(11):1128-1135. https://doi.org/10.1049/iet-map.2014.0167S1128113591

Blastic plasmacytoid dendritic cell neoplasm frequently shows occult central nervous system involvement at diagnosis and benefits from intrathecal therapy

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive myeloid neoplasm which shows a high rate of central nervous system (CNS) recurrence and overall survival (OS) of <1 year. Despite this, screening for CNS involvement is not routinely performed at diagnosis and intrathecal (IT) prophylaxis is not regularly administered in BPDCN. Here, we prospectively evaluated 13 consecutive BPDCN patients for the presence of CNS involvement by flow cytometry. Despite none of the patients presented with neurological symptoms, occult CNS involvement was detected in 6/10 cases evaluated at diagnosis and 3/3 studied at relapse/progression. BPDCN patients evaluated at diagnosis received IT treatment -either CNS prophylaxis (n = 4) or active therapy (n = 6)- and all but one remain alive (median follow-up of 20 months). In contrast, all three patients assessed at relapse/progression died. The potential benefit of IT treatment administered early at diagnosis on OS and CNS recurrence-free survival of BPDCN was further confirmed in a retrospective cohort of another 23 BPDCN patients. Our results show that BPDCN patients studied at diagnosis frequently display occult CNS involvement; moreover, they also indicate that treatment of occult CNS disease might lead to a dramatically improved outcome of BPDCN

COVID-19 Vaccination-Related Delayed Adverse Events among Patients with Systemic Lupus Erythematosus

BACKGROUND: The safety profile of COVID-19 vaccination is well documented, but hesitancy among people with immune-mediated inflammatory diseases, often immunocompromised, remains high, partially due to a scarcity of data on safety over a longer term. We herein aimed to assess delayed adverse events (DAEs) occurring &gt;7 days after COVID-19 vaccination in systemic lupus erythematosus (SLE) versus other rheumatic autoimmune diseases (rAIDs), non-rheumatic AIDs (nrAIDs), and healthy controls (HCs).METHODS: Self-reported data were captured within the COVID-19 Vaccination in Autoimmune Diseases (COVAD)-2 online survey, which comprised &gt;150 centres and responses from 106 countries, between February and June 2022. Logistic regression analysis adjusting for important confounders (age, sex, ethnicity) was used to compare groups.RESULTS: Of 7203 eligible individuals, 882 (12.2%) patients had SLE, 3161 (43.9%) patients had rAIDs, 426 (5.9%) patients had nrAIDs, and 2734 (38.0%) were HCs. SLE patients had a median age of 39 years (IQR: 31-50); 93.7% were women. SLE patients reported, more frequently, major DAEs (OR: 1.6; 95% CI: 1.2-2.0; p = 0.001) and hospitalisation (OR: 2.2; 95% CI: 1.4-3.4; p &lt; 0.001) compared to HCs, severe rashes (OR: 2.4; 95% CI: 1.3-4.2; p = 0.004) compared to people with rAIDS, and hospitalisation (OR: 2.3; 95% CI: 1.1-4.9; p = 0.029) as well as several minor DAEs compared to people with nrAIDs. Differences were observed between vaccines in terms of frequency of major DAEs and hospitalisations, with the latter seen more frequently in patients receiving the Moderna vaccine. People with SLE with no autoimmune multimorbidity less frequently reported overall minor DAEs compared to SLE patients with comorbid nrAIDs (OR: 0.5; 95% CI: 0.3-1.0; p = 0.036).CONCLUSION: Hospitalisations post-vaccination were more frequent in SLE patients than in HCs. Monitoring of SLE patients following COVID-19 vaccination can help in identifying DAEs early, informing patients about expected DAEs, and supporting patients, especially those with autoimmune multimorbidity.</p

Polymorphisms in the α4 Integrin of Neotropical Primates: Insights for Binding of Natural Ligands and HIV-1 gp120 to the Human α4β7

The α4 integrin subunit associates with β7 and β1 and plays important roles in immune function and cell trafficking. The gut-homing receptor α4β7 has been recently described as a new receptor for HIV. Here, we describe polymorphisms of ITGA4 gene in New World primates (NWP), and tested their impact on the binding to monoclonal antibodies, natural ligands (MAdCAM and VCAM), and several gp120 HIV-1 envelope proteins. Genomic DNA of NWP specimens comprising all genera of the group had their exons 5 and 6 (encoding the region of binding to the ligands studied) analyzed. The polymorphisms found were introduced into an ITGA4 cDNA clone encoding the human α4 subunit. Mutant α4 proteins were co-expressed with β7 and were tested for binding of mAbs, MAdCAM, VCAM and gp120 of HIV-1, which was compared to the wild-type (human) α4. Mutant α4 proteins harboring the K201E/I/N substitution had reduced binding of all ligands tested, including HIV-1 gp120 envelopes. The mAbs found with reduced biding included one from which a clinically-approved drug for the treatment of neurological disorders has been derived. α4 polymorphisms in other primate species may influence outcomes in the development and treatment of infectious and autoimmune diseases in humans and in non-human primates